SCID mice possess a genetic autosomal recessive mutation designated Prkdcscid.** They are homozygous for the Prkdcscid allele, which has been mapped to the centromeric end of chromosome 16. These mice have severe combined immunodeficiency affecting both B and T lymphocytes.
They lack functional lymphocytes because of impaired VDJ rearrangement (rearrangement of separate gene elements of the immunoglobulin and T-cell antigen receptor genes). While typical SCID mice are haired, our portfolio includes hairless models that make ideal candidates for tumor imaging and measurements:
