Developed by Dr. Lenny Shultz at The Jackson Laboratory, the JAX^® Mice strain NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) is commonly known as the NOD scid gamma (NSG^®). It is a mutant mouse which combines the features of the NOD/ShiLtJ background (conferring a number of deficiencies in innate immunity), the severe combined immune deficiency mutation (scid) and an IL2 receptor gamma chain deficiency which disables cytokine signalling. As a result, the NSG^® mice lack mature T cells, B cells, functional NK cells, and are also deficient in cytokine signaling.

Coat Color: White (albino)

Ideal For: Oncology, immunology, virology research, xenograft/transplant host (outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells)