Origin

Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.

Strain code

091

Coat color

Non-agouti brown

Research application

Genetic mapping, respiratory inflammation, immunological dysfunction, aging, transplantation research

MHC Haplotype

RT1n

Breeding location:

US, Germany, UK